RESEARCH INTEGRITY IN TIMES OF PANDEMIC

Research integrity in times of pandemic

In 1994, Douglas Graham Altman, one of the greatest statisticians of all time, wrote "We need less research, better research, and research weboost splitter done for good reasons".Twenty-seven years ago, Altman pointed out that the system favored unscientific behavior and that "bad science" was easy to publish, highlighting the financial implication

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Autistic Spectrum Disorder Detection and Structural Biomarker Identification Using Self-Attention Model and Individual-Level Morphological Covariance Brain Networks

Autism spectrum disorder (ASD) is a range of neurodevelopmental disorders, which brings enormous burdens to the families of patients and society.However, due to the lack of representation of variance for diseases and the absence of biomarkers for diagnosis, the early detection and intervention of ASD are remarkably challenging.In this study, we pro

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Adaptive designs in clinical trials: from scientific advice to marketing authorisation to the European Medicine Agency

Abstract Background In recent years, experience on the application of adaptive designs in confirmatory clinical trials has accumulated.Although planning such trials comes at the cost of additional operational complexity, adaptive designs offer the benefit of flexibility to update trial design and objectives weboost splitter as data accrue.In 2007,

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